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KMID : 0369819970270040279
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Jorunal of Korean Pharmaceutical Sciences
1997 Volume.27 No. 4 p.279 ~ p.286
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Solubilization of Ibuprofen in Aqueous Solution
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이장원/Lee JW
박은석/지상철/Park ES/Chi SC
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Abstract
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In order to formulate 2% ibuprofen solution, the effects of various solublizing agents, such as cosolvents (propylene glycol, polyethylene glycol, glycerin), a complexing agent (CELDEX®CH20), surfactants (PoloxamersandCremophor®RH40) on the solubility of ibuprofen in aqueous solution were evaluated. Among them, Poloxamer 407 and Cremophor® RH40 showed the excellent capacity on the solubilization of ibuprofen. After 2% ibuprofen solution of choice were administered orally to rats, in reference to a 2% ibuprofen syrup in the market, the pharmacokinetic parameters were determined. The absorption rate of ibuprofen from the solution was higher than that from the suspension.
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KEYWORD
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Ibuprofen, Solubilization, Pharmacokinetics
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